SELECTED PUBLICATIONS
Is HCCP (Osteo-P® BGS) the Next Gold Standard in Bone Grafting?

Explore the groundbreaking results published in Bioengineering MDPI and discover how we are setting a new standard in bone grafting.

Click the icon to read the full article and join the conversation about the future of bone regeneration.

Our Next-Generation Carbohydrate Polymer, HCCP (Osteo-P® BGS), is a Game-Changer for Chronic Metatarsal Pseudoarthrosis Repair
A 58-year-old man with no known risk factors suffered from chronic pain and first metatarsal pseudoarthrosis after four unsuccessful bone fusion surgeries. With amputation imminent, Osteo-P® BGS offered a new hope. Follow the story of minimally invasive, successful bridging, fusion and repair by clicking the icon.
Osteogenic Cells and Microenvironment of Early Bone Development and Clinical Implication
Frontiers in Spinal Neurosurgery, IntechOpen, 14 July 2023. Crossref, doi:10.5772/intechopen.1002037

Other Notable Publications

Koleva PM, Keefer JH, Ayala AM, et al. Hyper-Crosslinked Carbohydrate Polymer for Repair of Critical-Sized Bone Defects. Biores Open Access. 2019;8(1):111-120.

R. G, M. V, L. C. Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators. In: Duscher D. SM, ed. Regenerative Medicine and Plastic Surgery.: Springer, Cham; 2019:129-149.

Witzler M, Buchner D, Shoushrah SH, et al. Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration. Biomolecules. 2019;9(12):pii: E840.

Rao SS, Rekha PD, Anil S, Lowe B, Venkatesan J. Natural polysaccharides for growth factors delivery. In: Md Saquib Hasnain AKN, ed. Natural polysaccharides for growth factors delivery. Academic Press; 2019:495-512.

Ren B, Chen X, Du S, et al. Injectable polysaccharide hydrogel embedded with hydroxyapatite and calcium carbonate for drug delivery and bone tissue engineering. Int J Biol Macromol. 2018;118(Pt A):1257-1266.

Fan T, Chen J, Pan P, et al. Bioinspired double polysaccharides-based nanohybrid scaffold for bone tissue engineering. Colloids Surf B Biointerfaces. 2016;147:217-223.

Frasca S, Norol F, Le Visage C, et al. Calcium-phosphate ceramics and polysaccharide-based hydrogel scaffolds combined with mesenchymal stem cell differently support bone repair in rats. J Mater Sci Mater Med. 2017;28(2):35.

Gim S, Zhu Y, Seeberger PH, Delbianco M. Carbohydrate-based nanomaterials for biomedical applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019;11(5):e1558.

Hu J, Seeberger PH, Yin J. Using carbohydrate-based biomaterials as scaffolds to control human stem cell fate. Org Biomol Chem. 2016;14(37):8648-8658.

Deng Y, Ma F, Ruiz-Ortega LI, et al. Fabrication of strontium Eucommia ulmoides polysaccharides and in vitro evaluation of their osteoimmunomodulatory property. Int J Biol Macromol. 2019;140:727-735. – Copy not available

Tohamy KM, Soliman IE, Mabrouk M, et al. Novel polysaccharide hybrid scaffold loaded with hydroxyapatite: Fabrication, bioactivity, and in vivo study. Mater Sci Eng C Mater Biol Appl. 2018;93:1-11.

Kumar S, Majhi RK, Sanyasi S, Goswami C, Goswami L. Acrylic acid grafted tamarind kernel polysaccharide-based hydrogel for bone tissue engineering in absence of any osteo-inducing factors. Connect Tissue Res. 2018;59(sup1):111-121.

Baio JM, Walden RC, Fuentes TI, et al. A Hyper-Crosslinked Carbohydrate Polymer Scaffold Facilitates Lineage Commitment and Maintains a Reserve Pool of Proliferating Cardiovascular Progenitors. Transplant Direct. 2017;3(5):e153.

Batchelder CA, Martinez ML, Tarantal AF. Natural Scaffolds for Renal Differentiation of Human Embryonic Stem Cells for Kidney Tissue Engineering. PLoS One. 2015;10(12):e0143849.

Batchelder CA, Martinez ML, Duru N, Meyers FJ, Tarantal AF. Three Dimensional Culture of Human Renal Cell Carcinoma Organoids. PLoS One. 2015;10(8):e0136758.

Park H, Choi B, Nguyen J, et al. Anionic carbohydrate-containing chitosan scaffolds for bone regeneration. Carbohydr Polym. 2013;97(2):587-596.

Guerrero J, Catros S, Derkaoui SM, et al. Cell interactions between human progenitor-derived endothelial cells and human mesenchymal stem cells in a three-dimensional macroporous polysaccharide-based scaffold promote osteogenesis. Acta Biomater. 2013;9(9):8200-8213.